A Fusion of Forces

The first of its kind, P.E.A.R.L. Advanced Cell Signaling System combines Exosomes (or Biosomes) and PDRN in a singular, in-office aesthetic treatment, synergizing and amplifying the positive effects of both for more radiant, restored skin.

inside the science

Rewriting Regenerative Skincare

Developed by the foremost experts in Exosome and Biosome technology, P.E.A.R.L. drives better cell-to-cell communication, teaching skin to actually behave like its younger self.


By boosting bioavailability, our system reignites collagen, improves texture and strengthens the skin’s barrier, giving way to visibly smoother, more resilient, radiant-looking skin.

Used in combination with an ablative service—think radiofrequency microneedling—P.E.A.R.L. delivers a true breakthrough in regenerative aesthetics.

Cutting-Edge Ingredients in Synergy

Each ingredient, intentionally selected for its targeted role, works in harmony as part of a multifaceted approach to cellular-level regeneration. 

P - PDRN
 A Salmon DNA derivative that boosts tissue regeneration and DNA repair, improving elasticity and hydration
E - Exosomes (or Biosomes)
 Accelerates healing and cell regeneration and stimulates collagen and elastin production
A - Antioxidants
 Brightens, evens tone and protects against UV damage and environmental stressors
R - Recombinant Growth Factors
 A bio-signal cocktail that firms and brightens
L - Amino Acids
 Supports hydration and promotes a stronger skin barrier, firmer texture, and faster repair
After Protocol Before Protocol
After Protocol Before Protocol
After Protocol Before Protocol
After Protocol Before Protocol

Pioneering Approach, Proven Performance

After just two P.E.A.R.L. Fusion Services (over 8 weeks)*:

93%

said their skin feels more hydrated

86%

saw a visible reduction in fine lines and wrinkles

100%

said their skin looks brighter and more radiant

79%

noticed improved skin elasticity

100%

noticed an improvement in overall skin texture

93%

said their skin looks more youthful

86%

saw a noticeable improvement in hyperpigmentation

100%

would recommend a P.E.A.R.L. Fusion to others

*Patient-reported outcomes from an internal clinical evaluation.
Data on file, P.E.A.R.L. Advanced Cell-Signaling System, August 2025.

Highest Standards from Lab to Label

At AnteAGE®’s California headquarters, we adhere to academic best practices, following the International Society for Extracellular Vesicles’s (ISEV) guidelines and evolving our processes alongside breakthroughs in science, truly setting the bar in Exosome- and Biosome-specific sourcing and manufacturing.

EXOSOMES

The transmitters of transformation. Our hybrid-source Exosome solution features both bone marrow- and umbilical cord-derived mesenchymal stem cells (MSCs), which act as messengers of real, biological signals to drive cellular communication, coaching skin to repair from within.

BIOSOMES

Bioengineered for proven precision. Our Biosomes behave just as Exosomes do, but in a biosynthetic, lipid-based formula, ideal for those seeking a non-human-derived solution.

Experience the Power of P.E.A.R.L.

Schedule a consultation or treatment with a provider in your area today.

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